Spontaneous regression of chronic lymphocytic leukemia and simultaneous development of autoimmune hemolytic anemia and autoimmune thrombocytopenia

Autoimmune hemolytic anemia in chronic lymphocytic leukemia.

Autoimmune hemolytic anemia in chronic granulocytic leukemia.

A UTOIMMUNE HEMOLYTIC ANEMIA may complicate a wide variety of diseases, among which are infectious diseases, “collagen” diseases, benign tumors, malignant tumors, lymphomas and Hodgkin’s disease.1’2 The lymphoproliferative disorders, especially chronic lymphatic leukemia, have often been associated with abnormal immunologic mechanisms. The myeloproliferative disorders are rarely associated with...

Chronic lymphocytic leukemia, hypogammaglobulinemia and autoimmune hemolytic anemia--an experiment of nature.

BOUT a third of the patients with chronic lymphocytic leukemia develop hypogammaglobulinemia at some time or other during the course of their illness.’” The ensuing clinical manifestations are usually no different from those encountered in hypogammaglobulinemia from other causes; the patient may manifest an “immunologic paralysis” and is thereby rendered susceptible to infections of various kin...

Monoclonal immunoglobulin rescue from a patient with chronic lymphocytic leukemia and autoimmune hemolytic anemia.

In order to test whether autoimmune hemolytic anemia in a patient with chronic lymphocytic leukemia was due to autoantibody production by the neoplastic clone, somatic cell hybrids were constructed between the patient's leukemic cells and a mouse myeloma line. Light-chain-restricted human immunoglobulin was secreted by 4 of 11 of the established hybrid lines. No binding of this immunoglobulin t...

Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features.

Fifty-two cases of autoimmune hemolytic anemia (AHA) were observed within a series of 1203 patients (4.3%) with chronic lymphocytic leukemia (CLL) followed at a single institution. Nineteen were observed at the time of CLL diagnosis and 33 during the clinical follow-up. Ninety percent of the patients with CLL/AHA showed active CLL and 25% had been treated previously. The antierythrocyte autoant...